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Literature summary extracted from

  • Fiedler, F.; Glaser, L.
    The synthesis of polyribitol phosphate. II. On the mechanism of polyribitol phosphate polymerase (1974), J. Biol. Chem., 249, 2690-2695.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.14 CMP
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.14 CDPribitol + (ribitol phosphate)n Staphylococcus aureus
-
 CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + (ribitol phosphate)n Staphylococcus aureus H
-
 CMP + (ribitol phosphate)n+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.14 Staphylococcus aureus
-
 H
-
2.7.8.14 Staphylococcus aureus H
-
 H
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.8.14 n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.14 CDPribitol + (ribitol phosphate)n
-
 Staphylococcus aureus CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + (ribitol phosphate)n
-
 Staphylococcus aureus H CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid lipoteichoic acid carrier active with the Staphylococcus aureus enzyme can be extracted from Bacillus licheniformis, Lactobacillus casei, Lactobacillus plantarum, Streptococcus faecalis, Mycobacterium phlei, but not from a variety of other microorganisms Staphylococcus aureus lipoteichoic acid-(P-ribitol)n + CMP
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid single chain mechanism: the enzyme completes a chain of approximately 30 units linked to lipoteichoic acid carrier, before starting a new chain Staphylococcus aureus lipoteichoic acid-(P-ribitol)n + CMP
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid lipoteichoic acid carrier active with the Staphylococcus aureus enzyme can be extracted from Bacillus licheniformis, Lactobacillus casei, Lactobacillus plantarum, Streptococcus faecalis, Mycobacterium phlei, but not from a variety of other microorganisms Staphylococcus aureus H lipoteichoic acid-(P-ribitol)n + CMP
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid single chain mechanism: the enzyme completes a chain of approximately 30 units linked to lipoteichoic acid carrier, before starting a new chain Staphylococcus aureus H lipoteichoic acid-(P-ribitol)n + CMP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.14 8
-
 assay at Staphylococcus aureus